Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Promegestone
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DC Chemicals Limited
China
Product Name: Promegestone
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PROMEGESTONE
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Purity: 98.0%
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34184-77-5

34184-77-5 structure

34184-77-5 structure

Name: Promegestone
Chemical Name: promegestone
CAS Number: 34184-77-5
Molecular Formula: C₂₂H₃₀O₂
Molecular Weight: 326.47200
Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
Create Date: 2018-05-08 08:00:00
Modify Date: 2024-01-03 13:40:34
Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].

Name	promegestone
Synonyms	R5020 (8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one Promegestona Promegestone 17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione RU5020 Promegestonum promegestrone

Description	Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Cancer Research Areas >> Endocrinology
In Vitro	Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50 of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM)[1]. Promegestone is inactive in HELN cells that express luciferase but no functional receptor[1]. Promegestone (10 nM) robustly stimulates SLC37A2 expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models[3].
In Vivo	Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth[2].
References	[1]. Clémentine Garoche, et al. Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins. Environ Sci Technol. 2020 Aug 4;54(15):9510-9518. [2]. Michael A Kirby, et al. Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reprod Sci. 2016 Nov;23(11):1473-1483. [3]. Todd P Knutson, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10(1):89.

Density	1.09 g/cm3
Boiling Point	486.8ºC at 760 mmHg
Melting Point	152°
Molecular Formula	C₂₂H₃₀O₂
Molecular Weight	326.47200
Flash Point	180.4ºC
Exact Mass	326.22500
PSA	34.14000
LogP	5.17780
Index of Refraction	1.553

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG2965000

CHEMICAL NAME :: Estra-4,9-dien-3-one, 17-alpha-methyl-17-propionyl-

CAS REGISTRY NUMBER :: 34184-77-5

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H30-O2

MOLECULAR WEIGHT :: 326.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 20 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,373,1992