72040-63-2
72040-63-2 structure
- Name: Biotin-C5-NHS Ester
- Chemical Name: Succinimidyl-6-(biotinamido) Hexanoate
- CAS Number: 72040-63-2
- Molecular Formula: C20H30N4O6S
- Molecular Weight: 454.540
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-28 21:16:11
- Modify Date: 2026-06-30 07:16:44
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Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | Succinimidyl-6-(biotinamido) Hexanoate |
|---|---|
| Synonyms |
BIOTINYLAMIDOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER
6-[(+)-BIOTINYL]AMINOCAPROIC ACID N-HYDROXYSUCCINIMDE ESTER N-(+)-BIOTINYL-6-AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER SUCCINIMIDYL 6-[BIOTINAMIDO]HEXANOATE N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide Hexanoic acid, 6-[[5-[(3aS,4S,6-hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester N-Biotinyl-silon-aminocaproic acid N-hydroxysuccinimide ester Biotin-X, SE [Biotimidohexanoic acid N-hydroxysuccinimide ester] BiotinamidohexanoicacidN-hydroxysuccinimideester(biotin) Biotinamidohexanoic acid N-hydroxysuccinimide ester BIOTIN-X-NHS, WATER-SOLUBLE BIOTIN-X, SUCCINIMIDYL ESTER BIOTIN-X-NHS 6-(Biotinylamino)hexanoicacidN-hydroxysuccimideester SULFOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE BIOTINYL-SILON-AMINOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER Bachs N-SUCCINIMIDYL N-BIOTINYL-6-AMINOCAPROATE (+)-biotinyl-6-aminocaproic actd 2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6) D-BIOTIN-AMIDOCAPROATE-N-HYDROXYSUCCINIMIDE ESTER BIOTIN-AC5-OSU Biotinamidohexanoic acidN-hydroxysuccinimide ester (HPLC) Biotin-NHS LC (+)-Bioyinamidocaproate N-hydroxysuccinimidyl ester N-SucciniMidyl 6-BiotinaMidohexanoate 1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as-(3aalpha,4beta,6aalpha)) D-BIOTINYL-SILON-AMINOCAPROIC ACID-N-HYDROXY-SUCCINIMIDE ESTER (+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NHS ester, N-Succinimidyl N-biotinyl-6-aminocaproate, Succinimidyl 6-(biotinamido)hexanoate SULFO LC BIOTIN NHS-LC-BIOTIN Biotinyl-ε-aminocaproic acid-N-hydroxysuccinimide ester Biotin-6-aMinohexanoic acid-N-hydroxysucciniMide ester Biotin-LC-NHS SULFOSSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE 6-((BIOTINOYL)AMINO)HEXANOIC ACID, SUCCINIMIDYL ESTER Succinimidyl-6-biotinamide hexanoate N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide D-BIOTINOYL-SILON-AMINOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER N-(+)-BINTINY-6-AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER (+)-BIOTINY-6-AMINOCAPROIC ACTD CAS_72-2 Biotin-N-succinimidyl-amidohexanoate N-(+)-Biotinyl-6-aminohexanoic acid NHS ester (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate BIOTIN-X, SE MFCD00065502 Biotinyl-silon-aminohexanoic acid N-hydroxysuccinimide ester biotinyl-6-aminocaproic acid N-hydroxysuccinimide ester LC-NHS-(+)-Biotin 1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as,4S,6) (+)-BIOTINAMIDOCAPROATE N-HYDROXYSUCCINIMIDYL ESTER Biotinamidohexanoic acid N-hydroxysuccinimide ester,(+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NH BIOTINAMIDOCAPROATE N-HYDROXYSUCCINIMIDE ESTER 2,5-dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanaMido)hexanoate SULFOBIOTIN-X-NHS SULFO-NHS-LC-BIOTIN BIOTINAMIDOCAPROATE, N-HYDROXYSUCCINIMIDYL ESTER 6-[5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-4-YL)-PENTANOYLAMINO]-HEXANOIC ACID 3-HYDROPEROXYSULFONYL-2,5-DIOXO-PYRROLIDIN-1-YL ESTER SODIUM SALT BIOTIN-LC-OSU 2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)penta NHS-X-Biotin |
| Description | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 169-171 °C |
| Molecular Formula | C20H30N4O6S |
| Molecular Weight | 454.540 |
| Exact Mass | 454.188599 |
| PSA | 159.21000 |
| LogP | -1.62 |
| Index of Refraction | 1.591 |
| Storage condition | −20°C |
| Stability | Moisture Sensitive |
| Water Solubility | H2O: ≤2 mg/mL with sonication |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
~56%
72040-63-2 |
| Literature: Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655 |
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~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
|
~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
|
~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |