Biotin-C5-NHS Ester
Biotin-C5-NHS Ester structure
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Common Name | Biotin-C5-NHS Ester | ||
|---|---|---|---|---|
| CAS Number | 72040-63-2 | Molecular Weight | 454.540 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H30N4O6S | Melting Point | 169-171 °C | |
| MSDS | USA | Flash Point | N/A | |
Use of Biotin-C5-NHS EsterBiotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Succinimidyl-6-(biotinamido) Hexanoate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 169-171 °C |
| Molecular Formula | C20H30N4O6S |
| Molecular Weight | 454.540 |
| Exact Mass | 454.188599 |
| PSA | 159.21000 |
| LogP | -1.62 |
| Index of Refraction | 1.591 |
| InChIKey | UVGHPGOONBRLCX-NJSLBKSFSA-N |
| SMILES | O=C(CCCCC1SCC2NC(=O)NC21)NCCCCCC(=O)ON1C(=O)CCC1=O |
| Storage condition | −20°C |
| Stability | Moisture Sensitive |
| Water Solubility | H2O: ≤2 mg/mL with sonication |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~56%
Biotin-C5-NHS Ester CAS#:72040-63-2 |
| Literature: Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655 |
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~%
Biotin-C5-NHS Ester CAS#:72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
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~%
Biotin-C5-NHS Ester CAS#:72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
|
~%
Biotin-C5-NHS Ester CAS#:72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
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| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Avidin binding of carboxyl-substituted biotin and analogues.
Biochemistry 21 , 978-984, (1982)
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Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis.
J. Cell Biol. 139 , 1523-1531, (1997) Ligation of major histocompatability complex class I (MHC-I) molecules expressed on T cells leads to both growth arrest and apoptosis. The aim of the current study was to investigate the intracellular... |
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes Dev. 15 , 1067-1077, (2001) The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomi... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate |
| N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
| MFCD00065502 |
| N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: The English name of Succinimidyl-6-(biotinamido) Hexanoate is Succinimidyl-6-(biotinamido) Hexanoate. |
| Q: What is the LogP of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: LogP of Succinimidyl-6-(biotinamido) Hexanoate is -1.62. |
| Q: What English synonyms does Succinimidyl-6-(biotinamido) Hexanoate have? |
| A: English synonyms of Succinimidyl-6-(biotinamido) Hexanoate: (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate, N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide, MFCD00065502, N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide. |
| Q: What is the melting point of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: Melting point of Succinimidyl-6-(biotinamido) Hexanoate is 169-171 °C. |
| Q: How is the water solubility of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: Water solubility of Succinimidyl-6-(biotinamido) Hexanoate: H2O: ≤2 mg/mL with sonication. |
| Q: What are the storage conditions for Succinimidyl-6-(biotinamido) Hexanoate? |
| A: Storage conditions for Succinimidyl-6-(biotinamido) Hexanoate: −20°C. |
| Q: What is the CAS number of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: CAS number of Succinimidyl-6-(biotinamido) Hexanoate is 72040-63-2. |
| Q: What is the molecular formula of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: Molecular formula of Succinimidyl-6-(biotinamido) Hexanoate is C20H30N4O6S. |
| Q: What is the SMILES notation of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: SMILES notation of Succinimidyl-6-(biotinamido) Hexanoate is O=C(CCCCC1SCC2NC(=O)NC21)NCCCCCC(=O)ON1C(=O)CCC1=O. |
| Q: What are the upstream materials of Succinimidyl-6-(biotinamido) Hexanoate? |
| A: Related upstream materials(CAS) of Succinimidyl-6-(biotinamido) Hexanoate: 6066-82-6;72040-64-3;4443-68-9;85718-04-3;60-32-2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |