35795-16-5

35795-16-5 structure

Name: Trimazosin
Chemical Name: (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
CAS Number: 35795-16-5
Molecular Formula: C₂₀H₂₉N₅O₆
Molecular Weight: 435.47
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-05-26 08:00:00
Modify Date: 2024-01-06 20:52:59
Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2].

Name	(2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
Synonyms	trimazosine TRIMAZOSIN EINECS 252-732-7

Description	Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1-adrenergic receptor
In Vivo	Trimazosin (10–30 mg/kg; i.h.; once) produces graded decreases in blood pressure[3]. Animal Model: Conscious spontaneously hypertensive rats (SHR)[3] Dosage: 10–30 mg/kg Administration: Subcutaneous administration, once Result: Produced graded decreases in blood pressure.
References	[1]. J Vincent, et al. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608. [2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60. [3]. J. P. Buyniski, et al. Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension , 1980, Vol.2(6), p.1039-1066.