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135-19-3

135-19-3 structure
135-19-3 structure
Name 2-naphthol
Synonyms developerbn
β-naphthol
Developer AMS
Azogen Developer A
beta-Naphtol
Betanaphthol
EINECS 205-182-7
B-NAPHTOL
beta-Naftol
2-NAPHTHOL,PURIFIED
Developer NA
MFCD00004067
developerams
naphthyl hydroxide
2-Hydroxynaphthalene N-Hydroxy-N-nitrosobenzenamine ammonium salt
2-NAPHTHOL R. G., REAG. PH. EUR
iso-Napthol
c.i
BETA NAPHTHOL MIN
2-NAPHTHOL (BETA), FLUORESCENCE INDICATO R
β-Naphthyl alcohol
beta-Monoxynaphthalene
Naphthyl alcohol
2-HYDROXYNAPTHALENE
azoiccouplinomponent1
2-Naphtol
NAPHTHOL-2
Developer A
β-Monoxynaphthalene
2-NaphtholForSynthesis
2-NaphtholA.R
2-naphthol (beta)
developera
beta-naphthylhydroxide
c.i.azoiccouplinomponent1
Naphthol B
c.i.developer5
BETA NAPHTHO
Isonaphthol
betaNaphthol, Low Naphthalene
BetaNaphthol
b-NAPHTHOL extrapure
beta-Naftolo
b-Naphthyl alcohol
2-NAPHTHOL(β-NAPHTHOL)
2-NAPHTHOL POWDER
beta-Naphthyl alcohol
B-HYDROXYNAPHTHALENE
2-NAPHTHOL (BETA), FOR ANALYTICAL PURPOS ES
Beta Naphthol (2-Naphthol)
NAPHTHOL, B
2-Naphthalenol
β-hydroxynaphthalene
2-Naftolo
2-NAPHTHOL
2-Hydroxynaphthalene
beta-Naphthyl hydroxide
beta-naphthylalcohol
b-Naphthol
2-Naftol
Microcidin
Naphth-2-ol
azogendevelopera
Antioxygene BN
2-NAPHTHOL,REAGENT
B-NAPHTHOL WITH
Developer BN
2-Napththol
BETA NAPHTHOL ( 2-HYDROXY NAPHTHALENE)
naphthalen-2-ol
Description 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). 2-Naphthol (10, 25, 50 and 100 μM) causes no cytotoxic effect and the inhibition of peripheral-blood mononuclear cells proliferation[1].
References

[1]. Kapuci M, et al. Determination of cytotoxic and genotoxic effects of naphthalene, 1-naphthol and 2-naphthol on human lymphocyte culture. Toxicol Ind Health. 2014 Feb;30(1):82-9.
Density 1.2±0.1 g/cm3
Boiling Point 285.5±0.0 °C at 760 mmHg
Melting Point 120-122 °C(lit.)
Molecular Formula C10H8O
Molecular Weight 144.170
Flash Point 144.0±10.6 °C
Exact Mass 144.057510
PSA 20.23000
LogP 2.71
Vapour density 4.97 (vs air)
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.678
Storage condition Refrigerator
Stability Stable. Combustible. Dust may form explosive mixture with air. Incompatible with strong oxidizing agents, phenol.
Water Solubility 1 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL2975000
CHEMICAL NAME :
2-Naphthol
CAS REGISTRY NUMBER :
135-19-3
LAST UPDATED :
199710
DATA ITEMS CITED :
30
MOLECULAR FORMULA :
C10-H8-O
MOLECULAR WEIGHT :
144.18
WISWESSER LINE NOTATION :
L66J CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>770 mg/m3/1H
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2940 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
97500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2670 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10080 mg/kg/28D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 mg/kg/35W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - alteration of classical conditioning
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1350 ug/m3/17W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
298 mg/kg/35W-I
TOXIC EFFECTS :
Liver - liver function tests impaired

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
5 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,19,1977 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84296 No. of Facilities: 971 (estimated) No. of Industries: 18 No. of Occupations: 18 No. of Employees: 6346 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1957 No. of Facilities: 113 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 453 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84296 No. of Facilities: 199 (estimated) No. of Industries: 11 No. of Occupations: 26 No. of Employees: 10985 (estimated) No. of Female Employees: 590 (estimated)
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302 + H332-H400
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R20/22;R50
Safety Phrases S24/25-S61
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS QL2975000
Packaging Group III
Hazard Class 9
HS Code 2907151000
HS Code 2907151000
Summary HS:2907151000 naphthalen-2-ol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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title: CAS No. 135-19-3 | Chemsrc address: https://m.chemsrc.com/en/baike/954656.html

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