Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Diamfenetide
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DC Chemicals Limited
China
Product Name: Diamfenetide
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acetamide, N,N-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-
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Purity: 98.0%
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36141-82-9

36141-82-9 structure

36141-82-9 structure

Name: Diamfenetide
Chemical Name: N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide
CAS Number: 36141-82-9
Molecular Formula: C₂₀H₂₄N₂O₅
Molecular Weight: 372.41500
Catalog: Research Areas Infection
Create Date: 2018-09-21 22:15:50
Modify Date: 2024-01-20 14:31:00
Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].

Name	N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide
Synonyms	Diamfenetide bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether diamphenethide Coryphamin Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether N,N'-<Oxybis<2,1-(ethanediyloxy)-4,1-phenylene>>bisacetamide Acemidophene EINECS 252-886-5 Compound 68-198 Diamfenetidum [INN-Latin] Diamfenetida [INN-Spanish]

Description	Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].
Related Catalog	Research Areas >> Infection
In Vitro	Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2].
References	[1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol [2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C

Density	1.225g/cm3
Boiling Point	661.8ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅
Molecular Weight	372.41500
Flash Point	354.1ºC
Exact Mass	372.16900
PSA	85.89000
LogP	3.22380
Index of Refraction	1.595

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7042000

CHEMICAL NAME :: Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-

CAS REGISTRY NUMBER :: 36141-82-9

BEILSTEIN REFERENCE NO. :: 2179741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2-O5

MOLECULAR WEIGHT :: 372.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 22(4),59,1988

HS Code	2924299090

622-87-7 structure

622-87-7

64-19-7 structure

64-19-7

~96%

36141-82-9 structure

36141-82-9

Literature: Cablewski, Teresa; Gurr, Paul A.; Raner, Kevin D.; Strauss, Christopher R. Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5814 - 5817

5414-19-7 structure

5414-19-7

103-90-2 structure

103-90-2

~%

36141-82-9 structure

36141-82-9

Literature: Chen et al. Yaoxue Xuebao, 1959 , vol. 7, p. 149,152 Chem.Abstr., 1960 , p. 5528

Precursor 4
622-87-7 64-19-7 5414-19-7 103-90-2
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%