Diamfenetide

Modify Date: 2024-01-20 14:31:00

Diamfenetide Structure
Diamfenetide structure
 Common Name Diamfenetide
CAS Number 36141-82-9 Molecular Weight 372.41500
Density 1.225g/cm3 Boiling Point 661.8ºC at 760 mmHg
Molecular Formula C20H24N2O5 Melting Point N/A
MSDS N/A Flash Point 354.1ºC

 Use of Diamfenetide


Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].

 Names

Name N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide
Synonym More Synonyms

 Diamfenetide Biological Activity

Description Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].
Related Catalog
In Vitro Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2].
References

[1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol

[2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C

 Chemical & Physical Properties

Density 1.225g/cm3
Boiling Point 661.8ºC at 760 mmHg
Molecular Formula C20H24N2O5
Molecular Weight 372.41500
Flash Point 354.1ºC
Exact Mass 372.16900
PSA 85.89000
LogP 3.22380
Index of Refraction 1.595

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC7042000
CHEMICAL NAME :
Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-
CAS REGISTRY NUMBER :
36141-82-9
BEILSTEIN REFERENCE NO. :
2179741
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H24-N2-O5
MOLECULAR WEIGHT :
372.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
3150 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 22(4),59,1988

 Safety Information

HS Code 2924299090

 Synthetic Route

Benzene, 1,1-[oxybis (2,1-ethanediyloxy)]bis- structure

Benzene, 1,1-[o...

CAS#:622-87-7

acetic acid structure

acetic acid

CAS#:64-19-7

~96%

Diamfenetide Structure

Diamfenetide

CAS#:36141-82-9

Literature: Cablewski, Teresa; Gurr, Paul A.; Raner, Kevin D.; Strauss, Christopher R. Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5814 - 5817
Bis(2-bromoethyl) ether structure

Bis(2-bromoethy...

CAS#:5414-19-7

4-Acetamidophenol structure

4-Acetamidophenol

CAS#:103-90-2

~%

Diamfenetide Structure

Diamfenetide

CAS#:36141-82-9

Literature: Chen et al. Yaoxue Xuebao, 1959 , vol. 7, p. 149,152 Chem.Abstr., 1960 , p. 5528

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Diamfenetide
bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether
diamphenethide
Coryphamin
Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether
N,N'-<Oxybis<2,1-(ethanediyloxy)-4,1-phenylene>>bisacetamide
Acemidophene
EINECS 252-886-5
Compound 68-198
Diamfenetidum [INN-Latin]
Diamfenetida [INN-Spanish]
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