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314-03-4

314-03-4 structure

Name: Pimethixene
Chemical Name: pimethixene
CAS Number: 314-03-4
Molecular Formula: C₁₉H₁₉NS
Molecular Weight: 293.42600
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-03-02 08:00:00
Modify Date: 2024-01-02 12:33:55
Pimethixene is an antihistamine and anticholinergic agent, that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy.

Name	pimethixene
Synonyms	Calmixene 10-(1-methyl-4-piperidylidene)dibenzo[b,e]thiane 1-methyl-4-(9H-thioxanthen-9-ylidene)-piperidine 1-methyl-4-thioxanthen-9-ylidene-piperidine Calmixen 9-(N-methyl-piperidyliden-4-yl)-thioxanthene 9-(N-methyl-piperidyliden-4)-thioxanthene

Description	Pimethixene is an antihistamine and anticholinergic agent, that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease

Density	1.192g/cm3
Boiling Point	439.7ºC at 760mmHg
Molecular Formula	C₁₉H₁₉NS
Molecular Weight	293.42600
Flash Point	219.7ºC
Exact Mass	293.12400
PSA	28.54000
LogP	4.61660
Index of Refraction	1.661
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN1575000

CHEMICAL NAME :: Piperidine, 1-methyl-4-thioxanthen-9-ylidene-

CAS REGISTRY NUMBER :: 314-03-4

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H19-N-S

MOLECULAR WEIGHT :: 293.45

WISWESSER LINE NOTATION :: T C666 BS IYJ IU- DT6N DYTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

1445-73-4

492-22-8

314-03-4

Literature: FMC CORPORATION Patent: WO2004/26030 A2, 2004 ; Location in patent: Page 31 ;

138248-26-7

~87%

314-03-4

Literature: Honrubia, Maria Angeles; Jesus, Rodriguez; Dominguez, Rosa; Lozoya, Estrella; Manaut, Francesc; Seijas, Julio A.; Villaverde, Maria Carmen; Calleja, Jose M.; Cadavid, Maria Isabel; Maayani, Saul; Sanz, Ferran; Loza, Maria Isabel Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 842 - 848

3967-45-1

~64%

121360-49-4

314-03-4

Literature: Loughhead, David G. Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5701 - 5702

492-22-8

314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

29976-53-2

314-03-4

3967-45-1

314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

5570-77-4

314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

Precursor 4
1445-73-4 492-22-8 29976-53-2 5570-77-4
DownStream 0

314-03-4	13187-06-9
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
900500-24-5	6906-52-1
930439-75-1	1018584-77-4
2229173-05-9	1375289-11-4