Pimethixene

Modify Date: 2024-01-02 12:33:55

Pimethixene Structure
Pimethixene structure
Common Name Pimethixene
CAS Number 314-03-4 Molecular Weight 293.42600
Density 1.192g/cm3 Boiling Point 439.7ºC at 760mmHg
Molecular Formula C19H19NS Melting Point N/A
MSDS N/A Flash Point 219.7ºC

 Use of Pimethixene


Pimethixene is an antihistamine and anticholinergic agent, that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy.

 Names

Name pimethixene
Synonym More Synonyms

 Pimethixene Biological Activity

Description Pimethixene is an antihistamine and anticholinergic agent, that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy.
Related Catalog

 Chemical & Physical Properties

Density 1.192g/cm3
Boiling Point 439.7ºC at 760mmHg
Molecular Formula C19H19NS
Molecular Weight 293.42600
Flash Point 219.7ºC
Exact Mass 293.12400
PSA 28.54000
LogP 4.61660
Index of Refraction 1.661
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN1575000
CHEMICAL NAME :
Piperidine, 1-methyl-4-thioxanthen-9-ylidene-
CAS REGISTRY NUMBER :
314-03-4
LAST UPDATED :
199707
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C19-H19-N-S
MOLECULAR WEIGHT :
293.45
WISWESSER LINE NOTATION :
T C666 BS IYJ IU- DT6N DYTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

 Synthetic Route

~%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: FMC CORPORATION Patent: WO2004/26030 A2, 2004 ; Location in patent: Page 31 ;

~87%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Honrubia, Maria Angeles; Jesus, Rodriguez; Dominguez, Rosa; Lozoya, Estrella; Manaut, Francesc; Seijas, Julio A.; Villaverde, Maria Carmen; Calleja, Jose M.; Cadavid, Maria Isabel; Maayani, Saul; Sanz, Ferran; Loza, Maria Isabel Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 842 - 848

~64%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Loughhead, David G. Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5701 - 5702

~%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

~%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Honrubia, Maria Angeles; Jesus, Rodriguez; Dominguez, Rosa; Lozoya, Estrella; Manaut, Francesc; Seijas, Julio A.; Villaverde, Maria Carmen; Calleja, Jose M.; Cadavid, Maria Isabel; Maayani, Saul; Sanz, Ferran; Loza, Maria Isabel Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 842 - 848

~%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

~%

Pimethixene Structure

Pimethixene

CAS#:314-03-4

Literature: Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

 Synonyms

Calmixene
10-(1-methyl-4-piperidylidene)dibenzo[b,e]thiane
1-methyl-4-(9H-thioxanthen-9-ylidene)-piperidine
1-methyl-4-thioxanthen-9-ylidene-piperidine
Calmixen
9-(N-methyl-piperidyliden-4-yl)-thioxanthene
9-(N-methyl-piperidyliden-4)-thioxanthene
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