640281-90-9

640281-90-9 structure

Name: Valopicitabine
Chemical Name: [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2S)-2-amino-3-methylbutanoate
CAS Number: 640281-90-9
Molecular Formula: C₁₅H₂₄N₄O₆
Molecular Weight: 356.37400
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2017-04-18 23:38:39
Modify Date: 2024-01-10 16:05:55
Valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine, acts as a promising antiviral agent for reasearch of chronic HCV infection[1].

Name	[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2S)-2-amino-3-methylbutanoate
Synonyms	Valopicitabine [INN] NMC-283 NM-283 val-mCyd Valopicitabine UNII-I2T0B5G94M

Description	Valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine, acts as a promising antiviral agent for reasearch of chronic HCV infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HCV[1]
In Vivo	Valopicitabine (NM 283) has potent antiviral activity against chronic hepatitis C virus genotype-1 in the chimpanzee[1]. Valopicitabine exhibits moderate Cmax (3.62 ug/mL) and terminal elimination half-lives (T1/2 0.64 h) following oral administration (100 mg/kg) in Sprague-Dawley rats[2].
References	[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. [2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20.