61220-69-7

61220-69-7 structure
61220-69-7 structure
  • Name: Tiopinac
  • Chemical Name: 2-(11-oxo-6H-benzo[c][1]benzothiepin-3-yl)acetic acid
  • CAS Number: 61220-69-7
  • Molecular Formula: C16H12O3S
  • Molecular Weight: 284.33000
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-08-24 01:23:46
  • Modify Date: 2024-01-09 12:27:56
  • Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent.

Name 2-(11-oxo-6H-benzo[c][1]benzothiepin-3-yl)acetic acid
Synonyms UNII-1QX5LNW7CG
Tiopinacum
(11-oxo-6,11-dihydrodibenz[b,e]thiepin-3-yl)acetic acid
Tiopinacum [INN-Latin]
Tiopinac (USAN/INN)
Tiopinaco [INN-Spanish]
Tiopinaco
6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid
TIOPINAC
Description Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent.
Related Catalog
In Vivo Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].
Animal Admin Female rats, 160-180 g, receive 0.1 mL of a suspension in mineral oil of heatkilled M. butyricum (10 mg/mL) by means of two intradermal injections (0.05 mL each) into the proximal 1/4 of the tail on day 0. When the test agent is studied for its activity versus the development of the arthritic syndrome, it is administered p.o. (0.5 mL vehicle/dose) twice each day (at 9 a.m. and 4 p.m.) for 17 days, beginning on day 1. On day 18 the intensity of the swelling of the four foot pads and tail is determined blindly utilizing a scoring system in which the swelling in the four paws is scored 0-4 for each paw and the tail swelling is scored 0-3. The total maximum score is 19. The body weights and the weights of both hind paws are obtained. This procedure is a modification of a system initially described by PEARSON.
References

[1]. Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73.

Density 1.372g/cm3
Boiling Point 541.3ºC at 760 mmHg
Molecular Formula C16H12O3S
Molecular Weight 284.33000
Flash Point 281.1ºC
Exact Mass 284.05100
PSA 79.67000
LogP 3.15040
Index of Refraction 1.674
Storage condition 2-8℃
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%