61220-69-7
61220-69-7 structure
- Name: Tiopinac
- Chemical Name: 2-(11-oxo-6H-benzo[c][1]benzothiepin-3-yl)acetic acid
- CAS Number: 61220-69-7
- Molecular Formula: C16H12O3S
- Molecular Weight: 284.33000
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-08-24 01:23:46
- Modify Date: 2024-01-09 12:27:56
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Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent.
| Name | 2-(11-oxo-6H-benzo[c][1]benzothiepin-3-yl)acetic acid |
|---|---|
| Synonyms |
UNII-1QX5LNW7CG
Tiopinacum (11-oxo-6,11-dihydrodibenz[b,e]thiepin-3-yl)acetic acid Tiopinacum [INN-Latin] Tiopinac (USAN/INN) Tiopinaco [INN-Spanish] Tiopinaco 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid TIOPINAC |
| Description | Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent. |
|---|---|
| Related Catalog | |
| In Vivo | Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1]. |
| Animal Admin | Female rats, 160-180 g, receive 0.1 mL of a suspension in mineral oil of heatkilled M. butyricum (10 mg/mL) by means of two intradermal injections (0.05 mL each) into the proximal 1/4 of the tail on day 0. When the test agent is studied for its activity versus the development of the arthritic syndrome, it is administered p.o. (0.5 mL vehicle/dose) twice each day (at 9 a.m. and 4 p.m.) for 17 days, beginning on day 1. On day 18 the intensity of the swelling of the four foot pads and tail is determined blindly utilizing a scoring system in which the swelling in the four paws is scored 0-4 for each paw and the tail swelling is scored 0-3. The total maximum score is 19. The body weights and the weights of both hind paws are obtained. This procedure is a modification of a system initially described by PEARSON. |
| References |
| Density | 1.372g/cm3 |
|---|---|
| Boiling Point | 541.3ºC at 760 mmHg |
| Molecular Formula | C16H12O3S |
| Molecular Weight | 284.33000 |
| Flash Point | 281.1ºC |
| Exact Mass | 284.05100 |
| PSA | 79.67000 |
| LogP | 3.15040 |
| Index of Refraction | 1.674 |
| Storage condition | 2-8℃ |
| HS Code | 2934999090 |
|---|
| Precursor 10 | |
|---|---|
| DownStream 0 | |
![methyl 6,11 -dihydrodibenzo-[b.e.]-thiepin-11 -one-3 -acetate structure](https://image.chemsrc.com/caspic/147/61220-68-6.png)
![6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile structure](https://image.chemsrc.com/caspic/303/64976-83-6.png)
![potassium 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetate structure](https://image.chemsrc.com/caspic/499/61220-81-3.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |