435293-66-6

435293-66-6 structure

Name: 4-Hydroxyatomoxetine
Chemical Name: 3-methyl-4-[(1R)-3-(methylamino)-1-phenylpropoxy]phenol
CAS Number: 435293-66-6
Molecular Formula: C₁₇H₂₁NO₂
Molecular Weight: 271.35400
Catalog: Research Areas Neurological Disease
Create Date: 2017-05-07 08:59:00
Modify Date: 2024-01-10 08:56:57
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].

Name	3-methyl-4-[(1R)-3-(methylamino)-1-phenylpropoxy]phenol
Synonyms	UNII-6T2XYC0A9R 4`-Hydroxy Atomoxetine

Description	4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children. [2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.