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51-71-8

51-71-8 structure
51-71-8 structure
  • Name: Phenelzine
  • Chemical Name: 2-phenylethylhydrazine
  • CAS Number: 51-71-8
  • Molecular Formula: C8H12N2
  • Molecular Weight: 136.194
  • Catalog: API Nervous system medication Antidepressant, manic
  • Create Date: 2018-02-03 08:00:00
  • Modify Date: 2024-01-02 21:12:20
  • Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.

Name 2-phenylethylhydrazine
Synonyms MFCD00047825
Fenelzina
2-Phenelzine
Phenalzine
Phenelzine
(2-Phenethyl)hydrazine
Hydrazine,(2-phenylethyl)
(2-Phenylethyl)hydrazine
Nardil
1-(2-Phenethyl)hydrazine
Fenelzyne
b-Phenylethylhydrazine
Hydrazine, (2-phenylethyl)-
Phenelzinum
Fenelzyna
phenethyl hydrazine
N-(2-phenylethyl)hydrazine
EINECS 200-117-9
Description Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.
Related Catalog
Density 1.0±0.1 g/cm3
Boiling Point 281.4±19.0 °C at 760 mmHg
Molecular Formula C8H12N2
Molecular Weight 136.194
Flash Point 143.7±25.1 °C
Exact Mass 136.100052
PSA 38.05000
LogP 1.14
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.550
Storage condition 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MV8400000
CHEMICAL NAME :
Hydrazine, phenethyl-
CAS REGISTRY NUMBER :
51-71-8
BEILSTEIN REFERENCE NO. :
0742354
LAST UPDATED :
199801
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H12-N2
MOLECULAR WEIGHT :
136.22
WISWESSER LINE NOTATION :
ZM2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
39600 ug/kg/44D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis Behavioral - muscle contraction or spasticity
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
7500 ug/kg
TOXIC EFFECTS :
Behavioral - ataxia Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
122 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
450 mg/kg
SEX/DURATION :
male 4 day(s) pre-mating female 4 day(s) pre-mating - 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 10-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
38800 ug/kg/24H
REFERENCE :
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,1052,1986
Hazard Codes Xi: Irritant;
HS Code 2928000090

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51-71-8 structure

51-71-8

Literature: Votocek; Leminger Collection of Czechoslovak Chemical Communications, 1932 , vol. 4, p. 271,273, 280

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51-71-8 structure

51-71-8

Literature: Szmuszkovicz,J.; Greig,M.E. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, p. 259 - 296

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51-71-8 structure

51-71-8

Literature: Votocek; Leminger Collection of Czechoslovak Chemical Communications, 1932 , vol. 4, p. 271,273, 280
HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%