131926-98-2

131926-98-2 structure

Name: 5-Hydroxylansoprazole
Chemical Name: 5-hydroxy lansoprazole
CAS Number: 131926-98-2
Molecular Formula: C₁₆H₁₄F₃N₃O₃S
Molecular Weight: 385.36100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Proton Pump
Create Date: 2018-04-07 08:00:00
Modify Date: 2024-01-03 11:51:41
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].

Name	5-hydroxy lansoprazole
Synonyms	2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazol-5-ol 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylsulfinyl]-5-hydroxy-1H-benzimidazole AG-1908 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole-5-ol 5'-hydroxylansoprazole Lansoprazole Impurity 18

Description	5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
Target	Proton Pump[1]
References	[1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220. [2]. Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963(2019).