79352-78-6

79352-78-6 structure

Name: N-Desethyl amodiaquine
Chemical Name: n-desethyl amodiaquine dihcl
CAS Number: 79352-78-6
Molecular Formula: C₁₈H₁₈ClN₃O
Molecular Weight: 327.81
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-03-05 08:00:00
Modify Date: 2024-01-05 10:14:21
N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

Name	n-desethyl amodiaquine dihcl
Synonyms	N-Desethylamodiaquine 4-[(7-Chloro-4-quinolinyl)aMino]-2-[(ethylaMino)Methyl]phenol N-de-ethyl amodiaquine Desethylamodiaquine-[2H5] 4-[(7-Chloro-4-quinolyl)amino]-2-aminomethylphenol N-Desethylamodiaquine dihydrochloride desethylamodiaquine

Description	N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

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79352-78-6

Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

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79352-78-6

Literature: Journal of Medicinal Chemistry, , vol. 24, # 12 p. 1471 - 1475