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35449-36-6

35449-36-6 structure
35449-36-6 structure
  • Name: 1,10-Decanediol,2,2,9,9-tetramethyl-
  • Chemical Name: 2,2,9,9-tetramethyldecane-1,10-diol
  • CAS Number: 35449-36-6
  • Molecular Formula: C14H30O2
  • Molecular Weight: 230.39
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2016-01-18 00:14:28
  • Modify Date: 2025-08-21 10:53:32
  • Gemcadiol is a potent antilipemic agent. Gemcadiol has the potential for the research of hyperlipoproteinemia[1][2].
Name 2,2,9,9-tetramethyldecane-1,10-diol
Synonyms Gemcadiol
2,2,9,9-tetramethyl-decane-1,10-diol
2,2,9,9-Tetramethyl-1,10-decanediol
CI-720
2,2,9,9-Tetramethyl-1,10-decandiol
2,2,9,9-Tetramethyl-decan-1,10-diol
Description Gemcadiol is a potent antilipemic agent. Gemcadiol has the potential for the research of hyperlipoproteinemia[1][2].
Related Catalog
In Vivo Gemcadiol (25-300 mg/kg；13 周) 降低猴子的血清胆固醇并略微增加血清肌酸磷酸激酶[2]。
References

[1]. Blumethal HP, et al. Gemcadiol: a new antilipemic drug, a clinical trial. Lipids. 1977 Jan;12(1):44-8.  

[2]. Fitzgerald JE, et al. Preclinical toxicology studies with the lipid-regulating agent gemcadiol. Fundam Appl Toxicol. 1986 Apr;6(3):520-31.  

Density 0.904g/cm3
Boiling Point 319.3ºC at 760mmHg
Molecular Formula C14H30O2
Molecular Weight 230.39
Flash Point 136.7ºC
Exact Mass 230.22500
PSA 40.46000
LogP 3.36400
Index of Refraction 1.461

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HD8452000
CHEMICAL NAME :
1,10-Decanediol, 2,2,9,9-tetramethyl-
CAS REGISTRY NUMBER :
35449-36-6
BEILSTEIN REFERENCE NO. :
1748265
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H30-O2
MOLECULAR WEIGHT :
230.44
WISWESSER LINE NOTATION :
Q1X1&1&6X1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1023 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0064286
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1023 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10920 mg/kg/52W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
109 gm/kg/52W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986
HS Code 2905399090
22092-62-2 structure

22092-62-2

~%

35449-36-6 structure

35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141
22092-67-7 structure

22092-67-7

~%

35449-36-6 structure

35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141
158300-02-8 structure

158300-02-8

~%

35449-36-6 structure

35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141
Precursor  1

DownStream  0

HS Code 2905399090
Summary 2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%
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