1172118-03-4

1172118-03-4 structure

Name: PI3Kγ inhibitor 1
Chemical Name: N-[6-[4-amino-1-[[8-methyl-2-(2-methylphenyl)-1-oxoisoquinolin-3-yl]methyl]pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzothiazol-2-yl]acetamide
CAS Number: 1172118-03-4
Molecular Formula: C₃₂H₂₆N₈O₂S
Molecular Weight: 586.66600
Catalog: Research Areas Cancer
Create Date: 2017-11-03 18:05:41
Modify Date: 2024-01-11 17:22:12
PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.

Name	N-[6-[4-amino-1-[[8-methyl-2-(2-methylphenyl)-1-oxoisoquinolin-3-yl]methyl]pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzothiazol-2-yl]acetamide
Synonyms	PI3KGamma inhibitor 1 PI3Kγ inhibitor 1

Description	PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.
Related Catalog	Research Areas >> Cancer
Target	PI3Kδ:100 nM (IC50) PI3Kγ:100 nM (IC50) PI3Kα:10 μM (IC50) PI3Kβ:10 μM (IC50)
In Vitro	In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.
References	[1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.