883046-50-2

883046-50-2 structure

883046-50-2 structure

Name: S14161
Chemical Name: 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene
CAS Number: 883046-50-2
Molecular Formula: C₁₇H₁₄FNO₄
Molecular Weight: 315.30
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2017-08-22 02:45:24
Modify Date: 2023-10-17 20:19:35
Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].

Name	8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene
Synonyms	8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene 2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-

Description	Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73.

Density	1.3±0.1 g/cm3
Boiling Point	456.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄FNO₄
Molecular Weight	315.30
Flash Point	229.7±28.7 °C
Exact Mass	315.090698
PSA	64.28000
LogP	4.60
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.613

492-88-6 structure

492-88-6

706-08-1 structure

706-08-1

~87%

883046-50-2 structure

883046-50-2

Literature: Yin, Shu-Qiang; Shi, Min; Kong, Ting-Ting; Zhang, Cheng-Mei; Han, Kunkun; Cao, Biyin; Zhang, Zubin; Du, Xiaolin; Tang, Long-Qian; Mao, Xinliang; Liu, Zhao-Peng Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3314 - 3319

Precursor 2
492-88-6 706-08-1
DownStream 0