S14161

Modify Date: 2025-08-25 12:20:52

S14161 structure	Common Name	S14161
	CAS Number	883046-50-2	Molecular Weight	315.30
	Density	1.3±0.1 g/cm3	Boiling Point	456.2±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₄FNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	229.7±28.7 °C

Use of S14161

Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].

Name	8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene
Synonym	More Synonyms

Description	Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73.

Description

Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

References

[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97.

[2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73.

Density	1.3±0.1 g/cm3
Boiling Point	456.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄FNO₄
Molecular Weight	315.30
Flash Point	229.7±28.7 °C
Exact Mass	315.090698
PSA	64.28000
LogP	4.60
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.613