300586-90-7

300586-90-7 structure

Name: OAC1
Chemical Name: oac1
CAS Number: 300586-90-7
Molecular Formula: C₁₄H₁₁N₃O
Molecular Weight: 237.257
Catalog: Signaling Pathways Stem Cell/Wnt Oct3/4
Create Date: 2016-01-29 14:01:07
Modify Date: 2024-01-02 20:11:07
OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.IC50 value: Target: Oct4 activatorin vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.

Name	oac1
Synonyms	N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

Description	OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.IC50 value: Target: Oct4 activatorin vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Oct3/4 Research Areas >> Others
References	[1]. Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

RIDADR	NONH for all modes of transport