1204818-19-8

1204818-19-8 structure

Name: (R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID HYDROCHLORIDE
Chemical Name: (3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid,hydrochloride
CAS Number: 1204818-19-8
Molecular Formula: C₁₀H₁₁ClF₃NO₂
Molecular Weight: 269.648
Create Date: 2018-12-18 20:04:04
Modify Date: 2026-08-26 13:19:24

Name	(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid,hydrochloride
Synonyms	Sitalettinic acid Sitagliptin Impurity 17 Sitagliptin Acid Impurity HCl Sitagliptin Impurity 2 HCl Sitagliptin FP Impurity E Hydrochloride Sitagliptin Impurity 25 HCl Sitagliptin Tablets Impurity FP-E HCl (R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid HCl Sitagliptin Acid IMP A) (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride Benzenebutanoic acid, β-amino-2,4,5-trifluoro-, (βR)-, hydrochloride (1:1) Sitagliptin Impurity 4 HCl Sitagliptin Impurity 13 HCl Sitagliptin impurity 37/(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid hydrochloride Sitagliptin-2 (βR)-β-Amino-2,4,5-trifluorobenzenebutanoic Acid Hydrochloride (3R)-3-amino -4-(2, 4-difluorophenyl)-1-[3-(trifluoromethyl)butyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one (R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid hydrochloride Sitagliptin FP Impurity E (Sitagliptin Phosphate Monohydrate Acid Impurity) (3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid hydrochloride (1:1)

Hazard Codes	Xi
HS Code	2922499990

1374966-98-9

1204818-19-8

Literature: Drug Process Licensing Associates, LLC Patent: US2012/123144 A1, 2012 ; Location in patent: Page/Page column 4-5 ;

486460-00-8

~84%

1204818-19-8

Literature: Jiangsu Hengrui Medicine Co., Ltd. Patent: US2011/130587 A1, 2011 ; Location in patent: Page/Page column 5 ;

936630-57-8

~99%

1204818-19-8

Literature: Tasnadi, Gabor; Forro, Enik; Fueloep, Ferenc Organic and Biomolecular Chemistry, 2010 , vol. 8, # 4 p. 793 - 799

327-52-6

1204818-19-8

Literature: Drug Process Licensing Associates, LLC Patent: US2012/123144 A1, 2012 ;

209995-38-0

1204818-19-8

Literature: Jiangsu Hengrui Medicine Co., Ltd. Patent: EP2308829 A1, 2011 ;

1152439-73-0

1204818-19-8

Literature: Jiangsu Hengrui Medicine Co., Ltd. Patent: EP2308829 A1, 2011 ;

1151240-88-8

1204818-19-8

Literature: Jiangsu Hengrui Medicine Co., Ltd. Patent: EP2308829 A1, 2011 ;

1152439-74-1

1204818-19-8

Literature: Jiangsu Hengrui Medicine Co., Ltd. Patent: US2011/130587 A1, 2011 ;

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%