149007-54-5

149007-54-5 structure

Name: (S)-WAY 100135
Chemical Name: (2S)-3-[4-(2-Methoxyphenyl)-1-piperazinyl]-N-(2-methyl-2-propanyl )-2-phenylpropanamide dihydrochloride
CAS Number: 149007-54-5
Molecular Formula: C₂₄H₃₅Cl₂N₃O₂
Molecular Weight: 468.46
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-09-11 11:17:37
Modify Date: 2025-08-23 18:38:29
(S)-WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models[1].

Name	(2S)-3-[4-(2-Methoxyphenyl)-1-piperazinyl]-N-(2-methyl-2-propanyl )-2-phenylpropanamide dihydrochloride

Description	(S)-WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Cliffe IA, et al. (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J Med Chem. 1993 May 14;36(10):1509-10.