516-21-2

516-21-2 structure

Name: Cycloguanil
Chemical Name: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CAS Number: 516-21-2
Molecular Formula: C₁₁H₁₄ClN₅
Molecular Weight: 251.71500
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2017-02-03 07:08:42
Modify Date: 2024-01-09 23:39:03
Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

Name	1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
Synonyms	Cycloguanyl Cycloguanil 1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine Chlorcycloguanil WR 5473 Chlorguanide triazine 1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine 1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine 1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin

Description	Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

Density	1.4g/cm3
Boiling Point	400.7ºC at 760mmHg
Molecular Formula	C₁₁H₁₄ClN₅
Molecular Weight	251.71500
Flash Point	196.1ºC
Exact Mass	251.09400
PSA	75.00000
LogP	2.86690

HS Code	2933699090

4022-81-5

67-64-1

516-21-2

Literature: Loo Journal of the American Chemical Society, 1954 , vol. 76, p. 5096,5098 Full Text Show Details Bami; Modest; Levine Journal of Organic Chemistry, 1956 , vol. 21, p. 14,19 Full Text Show Details Carrington et al. Journal of the Chemical Society, 1954 , p. 1017,1026

20265-96-7

127099-85-8

67-64-1

516-21-2

Literature: Bami Journal of Scientific and Industrial Research, 1955 , vol. 14 C, p. 231,234 Full Text Show Details Basu; Sen Journal of Scientific and Industrial Research, 1952 , vol. 11 B, p. 312 Full Text Show Details Modest Journal of Organic Chemistry, 1956 , vol. 21, p. 1,12

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

516-21-2	25332-44-9
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