Cycloguanil

Modify Date: 2026-07-04 13:19:29

Cycloguanil structure	Common Name	Cycloguanil
	CAS Number	516-21-2	Molecular Weight	251.71500
	Density	1.4g/cm3	Boiling Point	400.7ºC at 760mmHg
	Molecular Formula	C₁₁H₁₄ClN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	196.1ºC

Use of Cycloguanil

Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

Name	1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
Synonym	More Synonyms

Description	Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

Density	1.4g/cm3
Boiling Point	400.7ºC at 760mmHg
Molecular Formula	C₁₁H₁₄ClN₅
Molecular Weight	251.71500
Flash Point	196.1ºC
Exact Mass	251.09400
PSA	75.00000
LogP	2.86690
InChIKey	QMNFFXRFOJIOKZ-UHFFFAOYSA-N
SMILES	CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1

HS Code	2933699090

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Literature: Loo Journal of the American Chemical Society, 1954 , vol. 76, p. 5096,5098 Full Text Show Details Bami; Modest; Levine Journal of Organic Chemistry, 1956 , vol. 21, p. 14,19 Full Text Show Details Carrington et al. Journal of the Chemical Society, 1954 , p. 1017,1026

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Literature: Bami Journal of Scientific and Industrial Research, 1955 , vol. 14 C, p. 231,234 Full Text Show Details Basu; Sen Journal of Scientific and Industrial Research, 1952 , vol. 11 B, p. 312 Full Text Show Details Modest Journal of Organic Chemistry, 1956 , vol. 21, p. 1,12

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Name: In vitro cytotoxicity against Plasmodium falciparum infected BC cell line.
Source: ChEMBL
Target: BC
External Id: CHEMBL651284

Name: Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus muscu...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL724608

Name: Antimalarial effect against trophozoite induced Plasmodium berghei in mice (Mus muscu...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL724607

Name: Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus muscu...
Source: ChEMBL
Target: Plasmodium berghei
External Id: CHEMBL718071

Name: Binding affinity towards mutant dihydrofolate reductase (A16V+S108T DHFR) of Plasmodi...
Source: ChEMBL
Target: Bifunctional dihydrofolate reductase-thymidylate synthase
External Id: CHEMBL663727

Name: Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye b...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL3635311

Name: Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Pl...
Source: ChEMBL
Target: Bifunctional dihydrofolate reductase-thymidylate synthase
External Id: CHEMBL663728

Name: Binding affinity to Escherichia coli DHFR assessed as change in melting temperature a...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL3635309

Name: Number of toxic deaths at a dose of 640 mg/kg
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL728195

Name: Inhibition of Escherichia coli DHFR assessed as NADP formation by quadratic Morrison ...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL3635314

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Cycloguanyl

Cycloguanil

1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine

Chlorcycloguanil

WR 5473

Chlorguanide triazine

1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine

1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine

1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine

1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin

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Product Name: Cycloguanil
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.