186371-96-0

186371-96-0 structure

Name: ZK168281
Chemical Name: Ethyl (2E)-3-{1-[(1S,3R,5Z,7E,22E,24R)-1,3,24-trihydroxy-9,10-sec ochola-5,7,10,22-tetraen-24-yl]cyclopropyl}acrylate
CAS Number: 186371-96-0
Molecular Formula: C₃₂H₄₆O₅
Molecular Weight: 510.70500
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2017-10-23 18:24:38
Modify Date: 2024-04-02 13:00:04
ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor[1].

Name	Ethyl (2E)-3-{1-[(1S,3R,5Z,7E,22E,24R)-1,3,24-trihydroxy-9,10-sec ochola-5,7,10,22-tetraen-24-yl]cyclopropyl}acrylate

Description	ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor[1].
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease
Target	Kd: 0.1 nM (VDR)[1]
In Vitro	ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus[1].
References	[1]. Lempiäinen H, et al. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol Endocrinol. 2005 Sep;19(9):2258-72.