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77094-11-2

77094-11-2 structure
77094-11-2 structure
  • Name: MeIQ
  • Chemical Name: 3,4-dimethylimidazo[4,5-f]quinolin-2-amine
  • CAS Number: 77094-11-2
  • Molecular Formula: C12H12N4
  • Molecular Weight: 212.25000
  • Catalog: Research Areas Cancer
  • Create Date: 2018-12-24 13:18:36
  • Modify Date: 2024-01-09 19:04:10
  • Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2].

Name 3,4-dimethylimidazo[4,5-f]quinolin-2-amine
Synonyms Methyl IQ
Me IQ
3,4-dimethyl-3H-imidazo<quinolin-2-amine
MelQ
2-amino-3,4-dimethylimidazo<4,5-f>quinoline
Description Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2].
Related Catalog
In Vitro Me-IQ (Methyl-IQ; 含0.04% 或0.01% 的饮食) 导致小鼠前胃鳞状细胞癌和乳头状瘤的发生率很高。0.04% 剂量组的 Me-IQ 诱发的前胃鳞状细胞癌中约40% 转移至肝脏[1]。
References

[1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105.  

[2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6.  

Density 1.36g/cm3
Boiling Point 465.7ºC at 760 mmHg
Melting Point 291-293ºC
Molecular Formula C12H12N4
Molecular Weight 212.25000
Flash Point 235.4ºC
Exact Mass 212.10600
PSA 56.73000
LogP 2.59330
Index of Refraction 1.725

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5907000
CHEMICAL NAME :
3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl-
CAS REGISTRY NUMBER :
77094-11-2
LAST UPDATED :
199807
DATA ITEMS CITED :
30
MOLECULAR FORMULA :
C12-H12-N4
MOLECULAR WEIGHT :
212.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5040 mg/kg/40W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7476 mg/kg/89W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22120 mg/kg/81W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27888 mg/kg/83W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Morphological transformation
TYPE OF TEST :
DNA damage
TYPE OF TEST :
DNA damage
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - guinea pig Lung
DOSE/DURATION :
10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993
Hazard Codes T: Toxic;
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%