103613-84-9

103613-84-9 structure

Name: (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt
Chemical Name: (2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met
CAS Number: 103613-84-9
Molecular Formula: C₅₀H₈₁N₁₅O₉
Molecular Weight: 1036.273
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-04-27 07:32:21
Modify Date: 2025-08-22 16:46:39
(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].

Name	(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met
Synonyms	H-MeTyr-Gly-Gly-Phe-Leu-Arg-MeArg-D-Leu-NHEt D-Leucinamide, N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-N-methyl-L-ornithyl-N-ethyl- N-Methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-N-methyl-L-ornithyl-N-ethyl-D-leucinamide N-Me-Tyr-gly-gly-phe-leu-arg-N-Me-arg-leu-NH-C2H5 N-Methyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-N-methyl-arginyl-leucyl ethylamide E-2078 D-Leucinamide,N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-N2-methyl-L-arginyl-N-ethyl C50H81N15O9 MeTyr-Gly-Gly-Phe-Leu-Arg-MeArg-D-Leu-NHEt

Description	(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	κ Opioid Receptor/KOR
References	[1]. Butelman ER, et al. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys. Psychopharmacology (Berl). 1999 Nov;147(1):73-80.