1204707-71-0

1204707-71-0 structure

Name: SRT3109
Chemical Name: N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R,3R)-3,4-dihydroxybutan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide
CAS Number: 1204707-71-0
Molecular Formula: C₁₈H₂₃F₂N₅O₄S₂
Molecular Weight: 475.533
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-12-02 10:02:49
Modify Date: 2024-01-18 17:26:48
SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.

Name	N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R,3R)-3,4-dihydroxybutan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide
Synonyms	Y0301 CS-0977 1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]- SRT-3109 cc-200 N-(2-[(2,3-Difluorobenzyl)sulfanyl]-6-{[(2R,3R)-3,4-dihydroxy-2-butanyl]amino}-4-pyrimidinyl)-1-azetidinesulfonamide SRT3109

Description	SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	CXCR2:8.2 (pIC50)
In Vitro	SRT3109 (Example 1) is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases[1].
References	[1]. Premji Meghani, et al. Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases. WO2010007427A1

Density	1.6±0.1 g/cm3
Boiling Point	726.6±70.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₃F₂N₅O₄S₂
Molecular Weight	475.533
Flash Point	393.3±35.7 °C
Exact Mass	475.115936
PSA	161.36000
LogP	2.07
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.661
Storage condition	2-8℃

654073-32-2

1204707-78-7

~62%

1204707-71-0

Literature: MEGHANI, PREMJI; ROBBINS, ANDREW JAMES; STONEHOUSE, JEFFREY PAUL Patent: US2010/16275 A1, 2010 ; Location in patent: Page/Page column 12 ;

1204707-81-2

~64%

1204707-71-0

Literature: MEGHANI, PREMJI; ROBBINS, ANDREW JAMES; STONEHOUSE, JEFFREY PAUL Patent: US2010/16275 A1, 2010 ; Location in patent: Page/Page column 14 ;

Precursor 3
654073-32-2 1204707-78-7 1204707-81-2
DownStream 0

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