13072-89-4

13072-89-4 structure

Name: 4,9-Anhydrotetrodotoxin
Chemical Name: (4R)-4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one
CAS Number: 13072-89-4
Molecular Formula: C₁₁H₁₄N₂O₂
Molecular Weight: 206.24100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2017-09-09 01:47:28
Modify Date: 2025-08-25 08:52:13
4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

Name	(4R)-4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one
Synonyms	Anhydro-epitetrodotoxin anhydrotetrodotoxin

Description	4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
In Vitro	4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].
References	[1]. Nicholas Denomme, et al. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 Apr 17;724:134853.

Precursor 2
5141-89-9 13285-84-2
DownStream 0