133740-30-4

133740-30-4 structure

Name: 1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol
Chemical Name: 1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol
CAS Number: 133740-30-4
Molecular Formula: C₂₂H₁₈O₄
Molecular Weight: 346.37600
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2017-09-14 22:19:27
Modify Date: 2024-03-10 10:38:10
BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1].

Name	1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol
Synonyms	1-(4-hydroxybenzyl)-4-methoxyphenthrene-2,7-diol 2,7-Phenanthrenediol,1-[(4-hydroxyphenyl)methyl]-4-methoxy 1-(4'-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol 1-(p-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol

Description	BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	BChE:2.1 ± 0.3 μM (IC50) AChE
In Vitro	BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively[1].BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82[1].
References	[1]. Liu Y, et al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.