1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol
Modify Date: 2024-03-10 10:38:10
![1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol Structure](https://image.chemsrc.com/caspic/243/133740-30-4.png)
1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol structure
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Common Name | 1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol | ||
|---|---|---|---|---|
| CAS Number | 133740-30-4 | Molecular Weight | 346.37600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diolBChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1]. |
| Name | 1-[(4-hydroxyphenyl)methyl]-4-methoxyphenanthrene-2,7-diol |
|---|---|
| Synonym | More Synonyms |
| Description | BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1]. |
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| Related Catalog | |
| Target |
BChE:2.1 ± 0.3 μM (IC50) AChE |
| In Vitro | BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively[1].BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82[1]. |
| References |
| Molecular Formula | C22H18O4 |
|---|---|
| Molecular Weight | 346.37600 |
| Exact Mass | 346.12100 |
| PSA | 69.92000 |
| LogP | 4.70920 |
| 1-(4-hydroxybenzyl)-4-methoxyphenthrene-2,7-diol |
| 2,7-Phenanthrenediol,1-[(4-hydroxyphenyl)methyl]-4-methoxy |
| 1-(4'-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol |
| 1-(p-hydroxybenzyl)-4-methoxyphenanthrene-2,7-diol |