3952-18-9

3952-18-9 structure

Name: Cupressuflavone
Chemical Name: cupressuflavone
CAS Number: 3952-18-9
Molecular Formula: C₃₀H₁₈O₁₀
Molecular Weight: 538.46
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-05-30 13:41:02
Modify Date: 2024-01-07 06:53:54
Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice[1][2][3].

Name	cupressuflavone
Synonyms	8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one 8,8'-Biapigenin Cupressuflavone

Description	Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Cupressuflavone (40-160 mg/kg; p.o. once daily for 5 days) 在肝脏和肾脏组织中通过增强抗氧化防御状态、减少脂质过氧化和防止 CCl4 诱导的病理变化来对抗氧化应激[1]。 Cupressuflavone (40-160 mg/kg; p.o.) 在40, 100, 160 mg/kg 剂量下分别抑制角叉菜胶诱导的炎症爪水肿 55%、60% 和 64%[2]。
References	[1]. Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71. [2]. Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28. [3]. Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34.