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Product Name: TYR-GLY-GLY-PHE-LEU-NH2
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Leucinamide,L-tyrosylglycylglycyl-L-phenylalanyl-
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60117-24-0

60117-24-0 structure

60117-24-0 structure

Name: Leu-Enkephalin amide acetate salt
Chemical Name: 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
CAS Number: 60117-24-0
Molecular Formula: C₂₈H₃₈N₆O₆
Molecular Weight: 554.63800
Catalog: Peptides
Create Date: 2018-12-27 23:02:44
Modify Date: 2025-08-23 15:17:12
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

Name	2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
Synonyms	Leu-enkephalinamide Leu-enkephalin Tyr-Gly-Gly-Phe-Leu-NH2 H-YGGFL-NH2 Enkephalinamide-leu leucine-enkephalin amide tyrosylglycylglycylphenylalanylleucinamide [Leu5]-Enkephalin, amide

Description	[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Peptides Research Areas >> Neurological Disease
Target	δ opioid receptor[1]
In Vitro	[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.1 nM[2].
In Vivo	Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].
References	[1]. Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.

Density	1.254 g/cm3
Boiling Point	1012.8ºC at 760 mmHg
Molecular Formula	C₂₈H₃₈N₆O₆
Molecular Weight	554.63800
Flash Point	566.3ºC
Exact Mass	554.28500
PSA	205.74000
LogP	2.20230
Index of Refraction	1.586

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