198022-65-0
- Name: Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI)
- Chemical Name: icofungipen
- CAS Number: 198022-65-0
- Molecular Formula: C7H11NO2
- Molecular Weight: 141.17
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2016-01-16 03:08:36
- Modify Date: 2025-09-29 18:28:10
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Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1].
| Name | icofungipen |
|---|---|
| Synonyms | Cyclopentane carboxylicacid,2-amino-4-methylene-,(1R,2S)-(9CI) |
| Description | Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Icofungipen 对念珠菌有抑制作用，MIC 值为 16-64 μg/mL（24-48 h 处理时间）[1]。 Icofungipen 对 90% 的念珠菌的 MIC90 值为 8-32 μg/mL[1]。 |
| In Vivo | Icofungipen（5-25 mg/kg；口服；每天两次，持续 7 天）在小鼠感染的致死模型中，剂量依赖性保护小鼠抵御白色念珠菌临床分离株的感染[1]。 |
| References |
| Density | 1.16g/cm3 |
|---|---|
| Boiling Point | 277.4ºC at 760 mmHg |
| Molecular Formula | C7H11NO2 |
| Molecular Weight | 141.17 |
| Flash Point | 121.6ºC |
| Exact Mass | 141.07900 |
| PSA | 63.32000 |
| LogP | 1.06480 |
| Vapour Pressure | 0.00123mmHg at 25°C |
| Index of Refraction | 1.528 |
|
~86%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
|
~%
198022-65-0 |
| Literature: Mittendorf, Joachim; Benet-Buchholz, Jordi; Fey, Peter; Mohrs, Klaus-Helmut Synthesis, 2003 , # 1 p. 136 - 140 |
