Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: holomycin
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Purity: 98.0%
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488-04-0

488-04-0 structure

488-04-0 structure

Name: holomycin-d3
Chemical Name: N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
CAS Number: 488-04-0
Molecular Formula: C₇H₆N₂O₂S₂
Molecular Weight: 214.26500
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-12-14 14:17:31
Modify Date: 2024-01-09 19:26:54
Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis[1].

Name	N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Synonyms	HOLOMYCIN N-Demethylthiolutin

Description	Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Paloma Liras, et al. Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus. Appl Microbiol Biotechnol. 2014 Feb;98(3):1023-30.

Density	1.632g/cm3
Boiling Point	532.147ºC at 760 mmHg
Molecular Formula	C₇H₆N₂O₂S₂
Molecular Weight	214.26500
Flash Point	275.633ºC
Exact Mass	213.98700
PSA	122.19000
LogP	2.62290
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.742

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7450000

CHEMICAL NAME :: Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-

CAS REGISTRY NUMBER :: 488-04-0

BEILSTEIN REFERENCE NO. :: 0188430

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2-O2-S2

MOLECULAR WEIGHT :: 214.27

WISWESSER LINE NOTATION :: T55 BMV FSSJ DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 22,233,1969

90993-81-0 structure

90993-81-0

75-36-5 structure

75-36-5

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488-04-0 structure

488-04-0

Literature: Hjelmgaard, Thomas; Givskov, Michael; Nielsen, John Organic and Biomolecular Chemistry, 2007 , vol. 5, # 2 p. 344 - 348

62698-47-9 structure

62698-47-9

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488-04-0 structure

488-04-0

Literature: Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-42-4 structure

62698-42-4

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488-04-0 structure

488-04-0

Literature: Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-45-7 structure

62698-45-7

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488-04-0 structure

488-04-0

Literature: Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-43-5 structure

62698-43-5

~%

488-04-0 structure

488-04-0

Literature: Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-44-6 structure

62698-44-6

~%

488-04-0 structure

488-04-0

Literature: Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

Precursor 6
75-36-5 62698-47-9 62698-42-4 62698-45-7
62698-43-5 62698-44-6
DownStream 1
488-03-9