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488-04-0

488-04-0 structure
488-04-0 structure
  • Name: holomycin-d3
  • Chemical Name: N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • CAS Number: 488-04-0
  • Molecular Formula: C7H6N2O2S2
  • Molecular Weight: 214.26500
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2017-12-14 14:17:31
  • Modify Date: 2024-01-09 19:26:54
  • Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis[1].
Name N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Synonyms HOLOMYCIN
N-Demethylthiolutin
Description Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis[1].
Related Catalog
References

[1]. Paloma Liras, et al. Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus. Appl Microbiol Biotechnol. 2014 Feb;98(3):1023-30.  

Density 1.632g/cm3
Boiling Point 532.147ºC at 760 mmHg
Molecular Formula C7H6N2O2S2
Molecular Weight 214.26500
Flash Point 275.633ºC
Exact Mass 213.98700
PSA 122.19000
LogP 2.62290
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.742

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB7450000
CHEMICAL NAME :
Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-
CAS REGISTRY NUMBER :
488-04-0
BEILSTEIN REFERENCE NO. :
0188430
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-N2-O2-S2
MOLECULAR WEIGHT :
214.27
WISWESSER LINE NOTATION :
T55 BMV FSSJ DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 22,233,1969

Chemsrc provides CAS#:488-04-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 488-04-0 | Chemsrc address: https://m.chemsrc.com/en/baike/996417.html

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