488-04-0

• 常用中文名：holomycin-d3
• 常用英文名：holomycin-d3
• CAS号：488-04-0
• 分子式：C₇H₆N₂O₂S₂
• 分子量：214.26500
• 相关类别： 信号通路 细胞周期/DNA损伤 DNA/RNA合成
• 发布时间：2017-12-14 14:17:31
• 更新时间：2024-01-09 19:26:54
• 荷莱霉素是二硫代吡咯啉酮类的次级代谢产物。博莱霉素也是一种广谱抗生素。荷莱霉素具有抗肿瘤活性,可在体内作用于RNA合成[1]。

名称

• 英文名: N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
• 英文别名: HOLOMYCIN; N-Demethylthiolutin

物化性质

• 密度: 1.632g/cm3
• 沸点: 532.147ºC at 760 mmHg
• 分子式: C₇H₆N₂O₂S₂
• 分子量: 214.26500
• 闪点: 275.633ºC
• 精确质量: 213.98700
• PSA: 122.19000
• LogP: 2.62290
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.742

生物活性

• 描述: 荷莱霉素是二硫代吡咯啉酮类的次级代谢产物。博莱霉素也是一种广谱抗生素。荷莱霉素具有抗肿瘤活性,可在体内作用于RNA合成[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 参考文献:

  [1]. Paloma Liras, et al. Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus. Appl Microbiol Biotechnol. 2014 Feb;98(3):1023-30.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AB7450000 CHEMICAL NAME : Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)- CAS REGISTRY NUMBER : 488-04-0 BEILSTEIN REFERENCE NO. : 0188430 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C7-H6-N2-O2-S2 MOLECULAR WEIGHT : 214.27 WISWESSER LINE NOTATION : T55 BMV FSSJ DMV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 22,233,1969

合成路线

90993-81-0 75-36-5 ~% 488-04-0

文献：Hjelmgaard, Thomas; Givskov, Michael; Nielsen, John Organic and Biomolecular Chemistry, 2007 , vol. 5, # 2 p. 344 - 348

62698-47-9 ~% 488-04-0

文献：Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-42-4 ~% 488-04-0

文献：Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-45-7 ~% 488-04-0

文献：Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-43-5 ~% 488-04-0

文献：Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

62698-44-6 ~% 488-04-0

文献：Ellis; Fried; Harrison; Rapp; Ross Journal of Organic Chemistry, 1977 , vol. 42, # 17 p. 2891 - 2893

上下游产品

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75-36-5 62698-47-9 62698-42-4 62698-45-7
62698-43-5 62698-44-6
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488-03-9