Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide

Modify Date: 2024-02-24 00:45:30

Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide Structure
Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide structure
 Common Name Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide
CAS Number 100307-95-7 Molecular Weight 583.64
Density 1.284g/cm3 Boiling Point 937.5ºC at 760 mmHg
Molecular Formula C28H37N7O7 Melting Point N/A
MSDS N/A Flash Point 520.8ºC

 Use of Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide


Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal[1].

 Names

Name 2-amino-N-[(2S)-1-[[2-[[(2S)-4-methyl-1-[[(2S)-2-[(4-nitrophenyl)methylamino]propanoyl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]benzamide
Synonym More Synonyms

 Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide Biological Activity

Description Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal[1].
Related Catalog
References

[1]. Everett MJ, et, al. Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models. ACS Infect Dis. 2023 Feb 10;9(2):270-282.  

 Chemical & Physical Properties

Density 1.284g/cm3
Boiling Point 937.5ºC at 760 mmHg
Molecular Formula C28H37N7O7
Molecular Weight 583.64
Flash Point 520.8ºC
Exact Mass 583.27500
PSA 233.01000
LogP 5.17060
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.595

 Synonyms

Aaglan
Abz-ala-gly-leu-ala-nba
2-Aminobenzoylalanyl-glycyl-leucyl-alanyl-4-nitrobenzylamide
2-Aminobenzoyl-ala-gly-leu-ala-4-nitrobenzylamide
L-Alaninamide,N-(2-aminobenzoyl)-L-alanylglycyl-L-leucyl-N-((4-nitrophenyl)methyl)-,(6aS-(6aalpha,7alpha,8beta,9aalpha))
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