A12B4C3
Modify Date: 2024-01-11 00:17:26
A12B4C3 structure
|
Common Name | A12B4C3 | ||
|---|---|---|---|---|
| CAS Number | 1005129-80-5 | Molecular Weight | 534.64700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H38N4O5 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of A12B4C3A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells[1]. |
| Name | 2-(1-hydroxyundecyl)-1-(4-nitroanilino)-6-phenyl-4a,7a-dihydro-2H-pyrrolo[3,4-b]pyridine-5,7-dione |
|---|---|
| Synonym | More Synonyms |
| Description | A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.06 μM (hPNKP)[1] |
| In Vitro | A12B4C3 (0-10 μM) strongly inhibits hPNKP phosphatase activity[1]. A12B4C3 (0-100 μM; 72 h) reduces A549 and MDA-MB-231 cell proliferation in a dose dependent manner[1]. A12B4C3 (1 μM; 24 h) increases the radiosensitivity of A549 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and MDA-MB-231 Concentration: 0, 1, 5, 10, 50 and 100 μM Incubation Time: 72 h Result: Reduced cell proliferation in a dose dependent manner, and up to ~50% at 100 μM. Cell Proliferation Assay[1] Cell Line: A549 and MDA-MB-231 (incubated with A12B4C3 for 2h then irradiated 0-10 Gy) Concentration: 1 μM Incubation Time: 24 h Result: Almost doubled the radiosensitivity of A549 cells. |
| References |
| Molecular Formula | C30H38N4O5 |
|---|---|
| Molecular Weight | 534.64700 |
| Exact Mass | 534.28400 |
| PSA | 118.70000 |
| LogP | 6.21110 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione |
| 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7-(2H,4aH)dione |
| A12B4C3 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: A12B4C3
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: A12B4C3
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: A12B4C3
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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