(R,S′)-MNF
Modify Date: 2023-01-11 22:39:10
(R,S′)-MNF structure
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Common Name | (R,S′)-MNF | ||
|---|---|---|---|---|
| CAS Number | 1007385-99-0 | Molecular Weight | 367.445 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R,S′)-MNF(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model. |
| Name | (R,S′)-MNF |
|---|
| Description | (R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model. |
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| References | 1. Artur Wnorowski, et al. Sci Rep. 2022 Mar 7;12(1):3618. |
| Molecular Formula | C22H25NO4 |
|---|---|
| Molecular Weight | 367.445 |