Trisodium phosphate dodecahydrate

Modify Date: 2025-08-21 01:19:58

Trisodium phosphate dodecahydrate Structure
Trisodium phosphate dodecahydrate structure
 Common Name Trisodium phosphate dodecahydrate
CAS Number 10101-89-0 Molecular Weight 380.18
Density 1.62 Boiling Point 158ºC at 760 mmHg
Molecular Formula H24Na36O16P Melting Point 75 °C
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Trisodium phosphate dodecahydrate


Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Trisodium phosphate dodecahydrate
Synonym More Synonyms

 Trisodium phosphate dodecahydrate Biological Activity

Description Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Armstrong R D, et al. Behaviour of sodium silicate and sodium phosphate (tribasic) as corrosion inhibitors for iron[J]. Journal of applied electrochemistry, 1994, 24: 1244-1248.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.62
Boiling Point 158ºC at 760 mmHg
Melting Point 75 °C
Molecular Formula H24Na36O16P
Molecular Weight 380.18
Exact Mass 380.049500
PSA 206.82000
Index of Refraction 1.4458
Storage condition Store at RT.
Stability Stable. Incompatible with strong acids. Keep dry.
Water Solubility 258 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TC9575000
CHEMICAL NAME :
Phosphoric acid, trisodium salt, dodecahydrate
CAS REGISTRY NUMBER :
10101-89-0
LAST UPDATED :
199504
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
O4-P.3Na.12H2-O
MOLECULAR WEIGHT :
380.18
WISWESSER LINE NOTATION :
NA3 P-O4 &QH 12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 257,791,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1585 No. of Facilities: 154 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 308 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1585 No. of Facilities: 3662 (estimated) No. of Industries: 36 No. of Occupations: 31 No. of Employees: 31308 (estimated) No. of Female Employees: 6999 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R35
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3262 8/PG 3
WGK Germany 1
RTECS TC9575000
Packaging Group III
Hazard Class 8
HS Code 2835291000

 Customs

HS Code 2835291000

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 Synonyms

trisodium,phosphate,dodecahydrate
Sodium phosphate,tribasic dodecahydrate
MFCD00149198
Sodium phosphate hydrate (3:1:12)
Phosphoric acid, trisodium salt, dodecahydrate
Trisodium phosphate dodecahydrate
Sodium phosphate tribasic dodecahydrate
EINECS 231-509-8
Phosphoric acid trisodium salt dodecahydrate
Sodium phosphate dodecahydrate
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