gadolinium chloride

Modify Date: 2024-01-06 09:47:54

gadolinium chloride structure	Common Name	gadolinium chloride
	CAS Number	10138-52-0	Molecular Weight	263.60900
	Density	4.52	Boiling Point	1580ºC
	Molecular Formula	Cl₃Gd	Melting Point	609ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of gadolinium chloride

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

Name	gadolinium trichloride
Synonym	More Synonyms

Description	Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> CaSR
Target	CaSR[1]
In Vitro	Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1]. In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1]. Western Blot Analysis[1] Cell Line: H9c2 cells Concentration: 30 μM Incubation Time: 15 minutes Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
References	[1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801.

Density	4.52
Boiling Point	1580ºC
Melting Point	609ºC
Molecular Formula	Cl₃Gd
Molecular Weight	263.60900
Exact Mass	262.83100
LogP	2.06850
Vapour Pressure	33900mmHg at 25°C

gadolinium chloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW4025000

CHEMICAL NAME :: Gadolinium chloride

CAS REGISTRY NUMBER :: 10138-52-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: Cl3-Gd

MOLECULAR WEIGHT :: 263.60

WISWESSER LINE NOTATION :: GD G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 378 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,437,1962 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R38
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	ZC0230000

gadolinium(III)...

CAS#:114364-08-8

gadolinium chloride

CAS#:10138-52-0

Literature: Thermochimica Acta, , vol. 320, # 1-2 p. 1 - 7

Precursor 1
CAS#:114364-08-8 gadolinium(III)...
DownStream 3
CAS#:16056-77-2 gadolinium acetate CAS#:13765-26-9 GADOLINIUM FLUORIDE CAS#:7647-01-0 Hydrochloric acid

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J. Phys. Chem. Lett. 6 , 2833-40, (2015)

A strategy to achieve 808 nm excited single-band red upconversion luminescence of Ho(3+) via the core-shell nanoarchitecture design was provided. Specifically, the synthesized Yb/Ho/Ce: NaGdF4@Yb/Nd: ...

Yttrium oxide/gadolinium oxide-modified platinum nanoparticles as cathodes for the oxygen reduction reaction.

ChemPhysChem 15(10) , 2136-44, (2014)

Rare-earth-element (Y, Gd) modified Pt nanoparticles (NPs) supported on a carbon substrate (Vulcan XC-72) are synthesized via a water-in-oil chemical route. In both cases, X-ray diffraction (XRD) meas...

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity.

J. Cell Physiol. 230 , 2086-97, (2015)

Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role ...

trichlorogadolinium

EINECS 233-386-6

Gadolinium(Iii) Chloride,Ultra Dry,Reo)

Gadolinium(III) chloride

MFCD00011024

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: gadolinium chloride
Price: ￥5858.0/25g ￥1308.0/5g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Gadolinium chloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Gadolinium chloride(GdCl3)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Gadolinium trichloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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