Olomoucine
Olomoucine structure
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Common Name | Olomoucine | ||
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| CAS Number | 101622-51-9 | Molecular Weight | 298.343 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 579.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H18N6O | Melting Point | 120-130 °C | |
| MSDS | Chinese USA | Flash Point | 304.3±32.9 °C | |
Use of OlomoucineOlomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2]. |
| Name | 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2]. |
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| Related Catalog | |
| Target |
cdk2-cyclin A:7 μM (IC50) cdk2-cyclin E:7 μM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.6±60.0 °C at 760 mmHg |
| Melting Point | 120-130 °C |
| Molecular Formula | C15H18N6O |
| Molecular Weight | 298.343 |
| Flash Point | 304.3±32.9 °C |
| Exact Mass | 298.154205 |
| PSA | 87.89000 |
| LogP | -0.08 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.691 |
| InChIKey | GTVPOLSIJWJJNY-UHFFFAOYSA-N |
| SMILES | Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21 |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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~89%
Olomoucine CAS#:101622-51-9 |
| Literature: Hocart, Charles H.; Letham, David S.; Parker, Charles W. Phytochemistry (Elsevier), 1991 , vol. 30, # 8 p. 2477 - 2486 |
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~70%
Olomoucine CAS#:101622-51-9 |
| Literature: Nugiel; Cornelius; Corbett Journal of Organic Chemistry, 1997 , vol. 62, # 1 p. 201 - 203 |
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Olomoucine CAS#:101622-51-9 |
| Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428 |
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Olomoucine CAS#:101622-51-9 |
| Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428 |
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~%
Olomoucine CAS#:101622-51-9 |
| Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428 |
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~%
Olomoucine CAS#:101622-51-9 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2697 - 2702 |
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Olomoucine CAS#:101622-51-9 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2697 - 2702 |
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~66%
Olomoucine CAS#:101622-51-9 |
| Literature: Dorff, Peter H.; Garigipati, Ravi S. Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2771 - 2773 |
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~%
Olomoucine CAS#:101622-51-9 |
| Literature: Phytochemistry (Elsevier), , vol. 25, # 2 p. 303 - 310 |
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Inhibition of cyclin-dependent kinases by purine analogues.
Eur. J. Biochem. 224 , 771, (1994) While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discov... |
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Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.
J. Neurosci. 34(21) , 7165-78, (2014) Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across... |
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Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
Biol. Cell 83 , 105-120, (1995) Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cycli... |
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Name: Inhibition of recombinant CDK2/cyclin A
Source: ChEMBL
Target: Cyclin-A2
External Id: CHEMBL1063859
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Name: Inhibition of recombinant CDK2/cyclin E
Source: ChEMBL
Target: G1/S-specific cyclin-E2
External Id: CHEMBL1063860
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1063858
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Inhibition of cGMP-dependent protein kinase
Source: ChEMBL
Target: N/A
External Id: CHEMBL822067
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Antiproliferative activity against K562 cell line
Source: ChEMBL
Target: K562
External Id: CHEMBL912431
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| OLO |
| olomoucine |
| 2-{[6-(Benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol |
| MFCD00189360 |
| Olomoucine,high purity |
| 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine |