Anecortave

Modify Date: 2024-01-08 12:26:07

Anecortave Structure
Anecortave structure
Common Name Anecortave
CAS Number 10184-70-0 Molecular Weight 344.44
Density N/A Boiling Point N/A
Molecular Formula C21H28O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anecortave


Anecortave (AL-4940) is an angiogenesis inhibitor. Anecortave is indicated for the study of exudative (wet) age-related macular degeneration as well as retinal tumors[1][2].

 Names

Name (8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
Synonym More Synonyms

 Anecortave Biological Activity

Description Anecortave (AL-4940) is an angiogenesis inhibitor. Anecortave is indicated for the study of exudative (wet) age-related macular degeneration as well as retinal tumors[1][2].
Related Catalog
References

[1]. Kaiser PK, et al. Posterior juxtascleral depot administration of anecortave acetate. Surv Ophthalmol. 2007 Jan;52 Suppl 1:S62-9.  

[2]. Jockovich ME, et al. Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1264-8.  

 Chemical & Physical Properties

Molecular Formula C21H28O4
Molecular Weight 344.44
Exact Mass 344.19900
PSA 74.60000
LogP 2.73090

 Synthetic Route

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Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Breslow, Ronald; Brandl, Michael; Hunger, Juergen; Adams, Alan D. Journal of the American Chemical Society, 1987 , vol. 109, # 12 p. 3799 - 3801

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Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Breslow, Ronald; Brandl, Michael; Hunger, Juergen; Adams, Alan D. Journal of the American Chemical Society, 1987 , vol. 109, # 12 p. 3799 - 3801

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Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Audouin, Max; Levisalles, Jacques Bulletin de la Societe Chimique de France, 1985 , # 6 p. 1280 - 1284

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Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

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Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Fried; Sabo Journal of the American Chemical Society, 1957 , vol. 79, p. 1130,1137

~%

Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Fried; Sabo Journal of the American Chemical Society, 1957 , vol. 79, p. 1130,1137

~%

Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

~%

Anecortave Structure

Anecortave

CAS#:10184-70-0

Literature: Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

 Synonyms

21-Desacetyl Anecortave
17,21-Dihydroxy-pregna-4,9(11)-dien-3,20-dion
17,21-dihydroxy-pregna-4,9(11)-diene-3,20-dione
(8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
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