Anecortave Acetate

Modify Date: 2025-08-20 08:38:45

Anecortave Acetate Structure
Anecortave Acetate structure
Common Name Anecortave Acetate
CAS Number 7753-60-8 Molecular Weight 386.48100
Density 1.23g/cm3 Boiling Point 551.8ºC at 760 mmHg
Molecular Formula C23H30O5 Melting Point N/A
MSDS N/A Flash Point 188.4ºC

 Use of Anecortave Acetate


Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

 Names

Name [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym More Synonyms

 Anecortave Acetate Biological Activity

Description Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
Related Catalog
Target

PAI-1[2]

In Vivo Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 551.8ºC at 760 mmHg
Molecular Formula C23H30O5
Molecular Weight 386.48100
Flash Point 188.4ºC
Exact Mass 386.20900
PSA 80.67000
LogP 3.30170
Index of Refraction 1.572

 Synthetic Route

 Synonyms

2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion
Retaane
21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
AL-3789
2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Anecortave
Anecortave acetate
Retaane suspension
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here






Get all suppliers and price by the below link:

Anecortave Acetate suppliers

Anecortave Acetate price