Anecortave Acetate

Modify Date: 2024-01-04 23:27:30

Anecortave Acetate structure	Common Name	Anecortave Acetate
	CAS Number	7753-60-8	Molecular Weight	386.48100
	Density	1.23g/cm3	Boiling Point	551.8ºC at 760 mmHg
	Molecular Formula	C₂₃H₃₀O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	188.4ºC

Use of Anecortave Acetate

Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

Name	[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym	More Synonyms

Description	Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Research Areas >> Cardiovascular Disease
Target	PAI-1[2]
In Vivo	Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.

Density	1.23g/cm3
Boiling Point	551.8ºC at 760 mmHg
Molecular Formula	C₂₃H₃₀O₅
Molecular Weight	386.48100
Flash Point	188.4ºC
Exact Mass	386.20900
PSA	80.67000
LogP	3.30170
Index of Refraction	1.572

Precursor 8
CAS#:50-03-3 Hydrocortisone ... CAS#:75868-48-3 21-chloro-17-hy... CAS#:63973-98-8 21-bromo-17-hyd... CAS#:3800-41-7 21-Acetoxy-9α-b...
CAS#:108674-98-2 (8S,9R,10S,13S,... CAS#:113862-93-4 21-Acetoxy-17α-... CAS#:566-35-8 11-Epicortisol CAS#:428516-04-5 21-acetoxy-3,3,...
DownStream 5
CAS#:514-36-3 Fludrocortisone... CAS#:2398-99-4 Androsta-4,9(11... CAS#:10184-70-0 Anecortave CAS#:10072-97-6 9beta,11beta-ep...
CAS#:127-31-1 fludrocortisone

2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion

Retaane

21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione

AL-3789

2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Anecortave

Anecortave acetate

Retaane suspension