Gardiquimod
Modify Date: 2024-01-02 16:11:47
Gardiquimod structure
|
Common Name | Gardiquimod | ||
|---|---|---|---|---|
| CAS Number | 1020412-43-4 | Molecular Weight | 313.39700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H23N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of GardiquimodGardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1][2]. |
| Name | 1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol |
|---|---|
| Synonym | More Synonyms |
| Description | Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
TLR7 TLR8 HIV-1 |
| In Vitro | Gardiquimod (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase[1]. |
| In Vivo | Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells[2]. Animal Model: Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)[2] Dosage: 1 mg/kg per mouse Administration: i.p.; daily for 7 days Result: Significantly suppressed the growth of human HepG2 liver carcinoma xenografts. |
| References |
| Molecular Formula | C17H23N5O |
|---|---|
| Molecular Weight | 313.39700 |
| Exact Mass | 313.19000 |
| PSA | 88.99000 |
| LogP | 3.01920 |
| Storage condition | 20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| Gardiquimod |
| gardiquimod |