4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-

Modify Date: 2024-01-10 14:09:40

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure
4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- structure
 Common Name 4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-
CAS Number 10212-30-3 Molecular Weight 243.22
Density 1.89g/cm3 Boiling Point 545.7ºC at 760mmHg
Molecular Formula C9H13N3O5 Melting Point N/A
MSDS N/A Flash Point 283.8ºC

 Use of 4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-


2-Amino-1-β-D-arabinofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-4-one

  Biological Activity

Description 2-Amino-1-β-D-arabinofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.89g/cm3
Boiling Point 545.7ºC at 760mmHg
Molecular Formula C9H13N3O5
Molecular Weight 243.22
Flash Point 283.8ºC
Exact Mass 243.08600
PSA 131.82000
Vapour Pressure 3.5E-14mmHg at 25°C
Index of Refraction 1.756

 Synthetic Route

2,2'-Cyclouridine structure

2,2'-Cyclouridine

CAS#:3736-77-4

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Ozaki, Hiroaki; Nakajima, Kiyohiro; Tatsui, Kaoru; Izumi, Chieko; Kuwahara, Masayasu; Sawai, Hiroaki Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2441 - 2443
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl acetate structure

[(2R,3S,4R,5R)-...

CAS#:6773-44-0

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
N/A structure

N/A

CAS#:102935-21-7

~%

2,2'-Cyclouridine structure

2,2'-Cyclouridine

CAS#:3736-77-4
4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1958 , p. 3028,3033 Full Text Show Details Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
2',3'-o-isopropylideneuridine structure

2',3'-o-isoprop...

CAS#:362-43-6

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
2',3'-O-(isopropylidene)uridine 5'-acetate structure

2',3'-O-(isopro...

CAS#:15922-23-3

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
Uridine structure

Uridine

CAS#:58-96-8

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
uridine triacetate structure

uridine triacetate

CAS#:4105-38-8

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1956 , p. 2388,2392 Journal of the Chemical Society, 1958 , p. 3028,3032
N/A structure

N/A

CAS#:102935-21-7

~%

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1958 , p. 3028,3033
O5'-acetyl-2'-iodo-2'-deoxy-uridine structure

O5'-acetyl-2'-i...

CAS#:109368-38-9

~%

2,2'-Cyclouridine structure

2,2'-Cyclouridine

CAS#:3736-77-4
4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl- Structure

4(1H)-Pyrimidin...

CAS#:10212-30-3
Literature: Brown et al. Journal of the Chemical Society, 1958 , p. 3028,3033
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Chemsrc provides CAS#:10212-30-3 MSDS, density, melting point, boiling point, structure, etc. Its name is 4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl->> amp version: 4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-

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