uridine triacetate

Modify Date: 2024-01-02 11:10:20

uridine triacetate Structure
uridine triacetate structure
 Common Name uridine triacetate
CAS Number 4105-38-8 Molecular Weight 370.311
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C15H18N2O9 Melting Point 124-134ºC
MSDS Chinese USA Flash Point N/A

 Use of uridine triacetate


Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].

 Names

Name 2',3',5'-Tri-O-acetyluridine
Synonym More Synonyms

 uridine triacetate Biological Activity

Description Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].
Related Catalog
References

[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356.

[2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 124-134ºC
Molecular Formula C15H18N2O9
Molecular Weight 370.311
Exact Mass 370.101227
PSA 142.99000
LogP -0.11
Index of Refraction 1.552
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles1

More Articles
Evaluation of molecularly imprinted polymers using 2',3',5'-tri-O-acyluridines as templates for pyrimidine nucleoside recognition.

Anal. Bioanal. Chem 406(25) , 6275-84, (2014)

In this paper, we describe the synthesis and evaluation of molecularly imprinted polymers (MIPs), prepared using 2',3',5'-tri-O-acyluridines as 'dummy' templates, for the selective recognition of urid...

 Synonyms

2',3',5-TRI-ACETYLURIDINE
EINECS 223-881-5
Vistogard
Uridine 2',3',5'-triacetate
2',3',5'-Tri-O-acetyl-rU
2’,3’,5’-Triacetyluridine
Uridine, 2',3',5'-triacetate
2`,3`,5`-Tracetyluridine
TAU
2',3',5'-Tri-O-acety
Tri-O-acetyl uridine
2',3',5'-Tri0acetyluridine
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
2',3',5'-Tri-O-acetyluridine
UNII-2WP61F175M
2',3',5'-Triacetyluridine
O2',O3',O5'-triacetyl-uridine
uridine triacetate
Xuriden
2',3',5'-O-triacetyluridine
2`,3`,5`-Triacetyluridine
2',3',5'-trioacetyluridine
MFCD00023795
Vistonuridine
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