OUL245
Modify Date: 2024-04-03 16:34:31
OUL245 structure
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Common Name | OUL245 | ||
|---|---|---|---|---|
| CAS Number | 1023814-45-0 | Molecular Weight | 191.21 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H5N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OUL245OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1]. |
| Name | OUL245 |
|---|
| Description | OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
PARP2:44 nM (IC50) PARP-1:570 nM (IC50) PARP3:8.8 μM (IC50) PARP4:6.0 μM (IC50) TNKS1:1.6 μM (IC50) TNKS2:370 μM (IC50) PARP10:2.9 μM (IC50) PARP14:6.7 μM (IC50) PARP15:2.0 μM (IC50) |
| In Vitro | OUL245 (1 μM; 10-12 d) 与其他衍生物不同，它不能拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡[1]。 药代动力学分析[1] water solubility μg/mL GI Papp×10-6 cm/s (RM %) BBB Papp×10-6 cm/s (RM %) metabolic stablity % stab in human plasma stab. in MeOH stab in PBS pH 7.4 24.91 0.019 0.164 95.05 >24 >24 >24 |
| References |
| Molecular Formula | C8H5N3OS |
|---|---|
| Molecular Weight | 191.21 |