1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-

Modify Date: 2024-01-02 20:00:47

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]- Structure
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]- structure
Common Name 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-
CAS Number 102392-05-2 Molecular Weight 393.48
Density N/A Boiling Point N/A
Molecular Formula C23H27N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-


NAN-190 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]

 Names

Name N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-phthalimide
Synonym More Synonyms

  Biological Activity

Description NAN-190 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]
Related Catalog
Target

5-HT1 Receptor

References

[1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76.  

[2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6.  

[3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.  

 Chemical & Physical Properties

Molecular Formula C23H27N3O3
Molecular Weight 393.48
Exact Mass 393.20500
PSA 53.09000
LogP 2.83440

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

NAN 190
1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide
1-(methoxyphenyl)-4-<4-(2-phthalimido)butyl>-piperazine hydrobromide
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