1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]

• 常用名: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]
• 英文名: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]
• CAS号: 102392-05-2
• 分子量: 393.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₇N₃O₃
• 熔点: N/A
• 闪点: N/A

用途

NAN-190是一种血清素受体5-HT受体拮抗剂, NAN-190是5-HT 1A选择性拮抗剂。

名称

• 英文名: N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-phthalimide

生物活性

• 描述: NAN-190是一种血清素受体5-HT受体拮抗剂, NAN-190是5-HT 1A选择性拮抗剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT1 Receptor

• 参考文献:

  [1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76.

  [2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6.

  [3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.

物理化学性质

• 分子式: C₂₃H₂₇N₃O₃
• 分子量: 393.48
• 精确质量: 393.20500
• PSA: 53.09000
• LogP: 2.83440
• InChIKey: SJDOMIRMMUGQQK-UHFFFAOYSA-N
• SMILES: COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1

靶点实验

查看更多实验

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal memb... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A External Id：CHEMBL615976

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Minimum effective agonist dose administered subcutaneously 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787825

实验名称：Minimum effective antagonist dose administered subcutaneously 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787826

实验名称：Validation qHTS for Identification of Calcium Integrin Binding protein 1 (CIB1) Compe... 来源：NCGC External Id：cib1-v1-fp-lopac

实验名称：In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydro... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A External Id：CHEMBL838856

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英文别名

• NAN 190
• 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
• 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide
• 1-(methoxyphenyl)-4-<4-(2-phthalimido)butyl>-piperazine hydrobromide