1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-

• 常用名: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-
• 英文名: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-
• CAS号: 102392-05-2
• 分子量: 393.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₇N₃O₃
• 熔点: N/A
• 闪点: N/A

用途

NAN-190是一种血清素受体5-HT受体拮抗剂, NAN-190是5-HT 1A选择性拮抗剂。

名称

• 英文名: N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-phthalimide

生物活性

• 描述: NAN-190是一种血清素受体5-HT受体拮抗剂, NAN-190是5-HT 1A选择性拮抗剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点:

  5-HT1 Receptor

• 参考文献:

  [1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76.

  [2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6.

  [3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.

物理化学性质

• 分子式: C₂₃H₂₇N₃O₃
• 分子量: 393.48
• 精确质量: 393.20500
• PSA: 53.09000
• LogP: 2.83440

英文别名

• NAN 190
• 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
• 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide
• 1-(methoxyphenyl)-4-<4-(2-phthalimido)butyl>-piperazine hydrobromide